Synergic Supressive Effect of the Combination Therapy with Silodosin and Imidafenacin on Non-voiding Contractions in Male Rats with Sub- Acute Bladder Outlet Obstruction
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چکیده
Hypothesis / aims of study Currently, the α1-adrenoceptor (α1-AR) antagonist/antimuscarinic combination appears to be a second-line add-on for patients with insufficient symptom relief after monotherapy in males with LUTS associated with bladder outlet obstruction (BOO) (1). However, no urodynamic evaluation has been reported on the effect of the combination therapy. In this study, first, by using precise frequency/volume (FV) and cystometry (CMG) measurements, we evaluated functional changes of LUT in a male rat model with subacute BOO. And then, we investigated that the effect of combination treatment with silodosin, an α1A-AR antagonist, and imidafenacin, a novel anticholinergic agent, on bladder function in this BOO rat model, and compared with that of each monotherapy.
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Comparative Influence of Imidafenacin and Oxybutynin on Voiding Function in Rats with Functional Urethral Obstruction.
An antimuscarinic therapy may increase the risk of voiding dysfunction. However, it is unclear whether the relative risk of voiding dysfunction is different among antimuscarinics. Therefore we determined the potencies both in enhancing the bladder capacity (BC), effectiveness, and in decreasing the maximum urinary flow rate (Qmax), voiding dysfunction, to compare their therapeutic indices.Under...
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